Buy Etizolam


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CAS ID: 40054-69-1
Formula: C17H15ClN4S
Biological half-life: 6.2 hours (main metabolite is 8.2 hours)
Metabolism: Hepatic
Dependence liability: Moderate
Price is per gram

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Etizolam is a psychoactive depressant and anxiolytic of the thienodiazepine class. The thienodiazepines are heterocylic compounds consisting of a thiophene ring fused to a diazepine ring.

Specifically etizolam departs from a benzodiazepine in structre in that the benzene ring is replaced with a thiopene and additionally a triazole is fused producing a thienotriazolodiazepine compound.

Etizolam has the formal and systematic IUPAC name 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. It has a relative molar mass of 342 grams and an empirical formula of C17H15ClN4S.

In vivo etizolam has a high bioavailability of 93 % and is readily absorbed from the alimentary canal. Metabolism of the drug is primarily at the liver with the drug having a biological half life of 6.2 hours and the primary metabolite having a half life of 8.2 hours. Excretion is by the renal route. It is classified as having a moderate liability for dependence and may be administered by oral, rectal and sublingual routes.

Etizolam is used as a medicine and marketed under the names PasadenDepasEtizestSedekopanEtilaamand Etizola.

Thienodiazeoines such as etizolam bind to the same site at GABAa as benzodiazepine. They produce similar effects as benzodiazepines and are considered almost identical. Other members of this drug class include metizolam and deschloroetizolam.

Etizolam is indicated for the short term management of insomnia and also as a short term agent in the management of anxiety and panic attacks. A common side effect of long term usage is blepharospasm or the involuntary twitching of the eyelid.

It has anxiolytic, anticonvulsant, hypnotic and amnesic qualities. It is a skeletal muscle relaxant.

As is the case with benzodiazepines, etizolam produces dependence with long term usage.  Rapid withdrawal is known to produce an acute and negative syndrome known as benzodiazepine withdrawal syndrome. Symptoms include disturbance of sleep, increased anxiety, tension, panic attacks, tremor, sweating, impaired concentration, states of confusion, difficulty thinking, memory impairment, nausea and dry retching, loss of weight, headache, palpitations, muscular pain and even hallucinations, psychosis and seizures.

Benzodiazipine withdrawal symptom can be very severe and produce significant impairment on quality of life. It has in fact been linked with suicide. Symptoms present in the acute stages and some linger for a number of years. The symptoms are characterised by increasing or decreasing in severity and coming and going day to day or week to week. These adverse symptoms do not fall off in a reliable monotonic manner.

Such effects of withdrawal naturally mean that users are compelled to continue using the medicine in a long term manner. It is for this reason that etizolam is prescribed for short term usage. Withdrawal after long term use must be approached by a gradual tapering down of dosage and not abrupt withdrawal.

Etizolam is a prescription medicine and not for recreational usage.

It is a substance of abuse however. Unverifiable online reports claim cognitive effects of anxiety suppression, disinhibition, amnesia, euphoria, suppression of emotion and potentiation of dreams.

Users may act under the impression that they are sober when this is not the case. Etizolam also is associated with a compulsion to redoes.

It has a low toxicity relative to dose buy should not be combined with other depressive agents like alcohol, GBH/ GBL or opioids. Such combinations can be lethal.